当前位置:首页>深圳>全国非公医疗机构首方!深圳前海泰康医院开出口服靶向药“瑞普多”,为荨麻疹患者带来精准治疗新选择

全国非公医疗机构首方!深圳前海泰康医院开出口服靶向药“瑞普多”,为荨麻疹患者带来精准治疗新选择

  • 2026-04-18 23:36:58
全国非公医疗机构首方!深圳前海泰康医院开出口服靶向药“瑞普多”,为荨麻疹患者带来精准治疗新选择

3月25日,深圳前海泰康医院皮肤科刘慧瑜副主任医师为一位慢性自发性荨麻疹(CSU)患者开出了全国非公医疗机构首张瑞普多®(瑞米布替尼片)电子处方。这标志着这款拥有全新作用机制的创新口服靶向药正式进入深圳临床,为粤港澳大湾区以及全国广大CSU患者带来了高效、便捷的治疗新选择。

皮肤科刘慧瑜副主任医师为患者开出瑞普多®(瑞米布替尼片)电子处方

临床困境

半数患者面临传统治疗应答不佳

慢性自发性荨麻疹是一种以反复、不可预测的瘙痒性风团和/或血管性水肿为特征的皮肤病,严重困扰患者身心健康。数据显示,超过80%的中国患者饱受瘙痒反复发作之苦,近一半患者伴有焦虑或抑郁情绪[1]。尽管常规抗组胺药是基础治疗,但仍有约50%-60%的患者在增加剂量或联合用药后症状控制不佳[2]。而传统的二线治疗方案,或因长期使用存在副作用风险,或因需要注射给药,让部分患者望而却步。临床上迫切需要起效更快、疗效更优、使用更便捷的创新治疗手段。

革新机制

从源头阻断核心信号通路的靶向药物

瑞米布替尼是全球首个且目前唯一获批用于治疗CSU的高选择性口服小分子布鲁顿酪氨酸激酶(BTK)抑制剂[3-5]。不同于传统药物,它能够精准作用于CSU发病的核心通路——FcεRI信号通路的枢纽BTK,从细胞内部源头阻断肥大细胞和嗜碱性粒细胞释放组胺等炎症介质。这种“胞内阻断”机制使其能有效应对CSU的不同免疫内型,直击疾病核心。

瑞普多®(瑞米布替尼片)商品图

临床研究数据

疗效表现与生活质量改善

基于两项关键全球III期临床研究,瑞米布替尼显示出以下疗效数据:

1.起效时间:治疗1周时,有50%的患者达到有临床意义的应答标准[6]

2.应答率:治疗12周时,近90%的患者获得应答[6]。不同病程、病情严重程度或既往治疗史的患者均可观察到疗效。

3.长期数据:治疗至52周时,症状改善持续稳定[7]

4.生活质量:治疗12周时,约半数患者的睡眠和日常活动得到改善。

安全便捷

口服给药简化长期管理流程

瑞米布替尼的整体安全性与耐受性良好。在关键临床研究中,其不良事件发生率与安慰剂相当,最常见的不良反应为上呼吸道感染。

本品为口服制剂,每日两次,无需注射;无需用药前特殊筛查或用药期间的常规实验室监测无需冷藏储存,便于携带,为患者长期管理提供了便利。

适用人群

为特定需求患者提供新选择

瑞米布替尼适用于H1抗组胺药控制不佳的成人CSU患者,为以下特定需求的患者提供了新的治疗选择:

1.希望快速控制症状、恢复正常生活的患者。

2.因严重瘙痒导致睡眠障碍和日间功能受损的患者。

3.因疾病反复而产生焦虑、抑郁情绪的患者。

4.惧怕注射或认为注射治疗不便的患者。

5. 合并自身免疫性疾病等共病的CSU患者。

指南推荐

临床治疗的新方案

瑞米布替尼的临床价值已获国内外权威指南一致认可,均将其推荐为抗组胺药控制不佳CSU患者的二线治疗方案。这款口服靶向药物,以其明确的临床数据,为CSU治疗提供了新的选择。

用药提醒

瑞普多®(瑞米布替尼片)为处方药,需在医生指导下使用。如果您正受慢性自发性荨麻疹困扰,请务必前往正规医疗机构,由皮肤科专业医生进行全面评估后,判断是否适用本药物,切勿自行购药或用药。

咨询方式

如您想了解更多关于瑞普多®(瑞米布替尼片)的用药信息,欢迎添加深圳前海泰康医院皮肤科小助手,工作人员将为您提供解答与帮助。

扫码添加皮肤科小助手

参考文献:

[1] Balp M, et al. Patient 2015;8(6):551-558.

[2] Guillen-Aguinaga S, et al. British J Derm. 2016;175:1153-1165.

[3] Angst D, et al. J Med Chem., 2020;63:5102-5118.

[4] Bernstein L, et al., Jillergy Clin Immunol. 202,453(5):1229-1240.

[5] Martin Metz, et al., N Engly J Med. 2025 Mar 6; 392(10): 984-994.

[6] Maurer M, et al. President at EADCV Congress 2024, 25:28 September, Amsterdam, Abstract P3625.

[7] Met, Met al. Oral presented at EAAC1 2024, May 31-June 3; Valencia, Spain. Late oral session L-OAS-CT 01.

审核丨皮肤科 刘慧瑜

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  1. CONNECT:[ UseTime:0.000451s ] mysql:host=127.0.0.1;port=3306;dbname=c460;charset=utf8mb4
  2. SHOW FULL COLUMNS FROM `fenlei` [ RunTime:0.000642s ]
  3. SELECT * FROM `fenlei` WHERE `fid` = 0 [ RunTime:0.000938s ]
  4. SELECT * FROM `fenlei` WHERE `fid` = 63 [ RunTime:0.000367s ]
  5. SHOW FULL COLUMNS FROM `set` [ RunTime:0.000484s ]
  6. SELECT * FROM `set` [ RunTime:0.000200s ]
  7. SHOW FULL COLUMNS FROM `article` [ RunTime:0.000528s ]
  8. SELECT * FROM `article` WHERE `id` = 528352 LIMIT 1 [ RunTime:0.000916s ]
  9. UPDATE `article` SET `lasttime` = 1776578148 WHERE `id` = 528352 [ RunTime:0.002449s ]
  10. SELECT * FROM `fenlei` WHERE `id` = 64 LIMIT 1 [ RunTime:0.000265s ]
  11. SELECT * FROM `article` WHERE `id` < 528352 ORDER BY `id` DESC LIMIT 1 [ RunTime:0.002779s ]
  12. SELECT * FROM `article` WHERE `id` > 528352 ORDER BY `id` ASC LIMIT 1 [ RunTime:0.000439s ]
  13. SELECT * FROM `article` WHERE `id` < 528352 ORDER BY `id` DESC LIMIT 10 [ RunTime:0.000687s ]
  14. SELECT * FROM `article` WHERE `id` < 528352 ORDER BY `id` DESC LIMIT 10,10 [ RunTime:0.001129s ]
  15. SELECT * FROM `article` WHERE `id` < 528352 ORDER BY `id` DESC LIMIT 20,10 [ RunTime:0.000824s ]
0.117665s