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今晚直播| 深圳先进院Neuron共同通讯作者报告限制酒精奖赏的新神经机制

  • 2026-06-14 07:52:49
今晚直播| 深圳先进院Neuron共同通讯作者报告限制酒精奖赏的新神经机制

酒精使用障碍是一种慢性且易复发的脑疾病，其核心特征之一是奖赏驱动力的异常增强。然而，大脑如何在高强化奖赏情境下限制这种过度的奖赏驱动，仍缺乏清晰的机制认识。

近日，中国科学院深圳先进技术研究院脑认知与脑疾病研究所/深港脑科学创新研究院朱英杰、陈子君团队等在国际神经科学期刊 Neuron 在线发表题为“A septal inhibitory circuit constrains alcohol reward and mediates liraglutide's suppressive effects on alcohol intake in mice”的研究论文。该研究发现，外侧隔核（lateral septum, LS）中的GLP-1R神经元通过抑制腹侧LS神经元，形成局部抑制性微环路，从而降低酒精诱导的伏隔核多巴胺释放并抑制饮酒行为。该研究揭示了一个关键的神经环路机制，用于限制高强化奖赏的表达。

2026年5月8日（周五）晚19:00，Brainnews与Cell Press出版社官方联合主办的Cell Press脑科学讲坛（第十七期）有幸邀请到以上研究的通讯作者陈子君副研究员与我们面对面作报告。

本次报告将结合此前在摄食及享乐性进食领域的研究，进一步探讨外侧隔核在不同类型奖赏行为中的共同调控作用，提出其作为“奖赏驱动力限制器”的统一功能框架，为理解成瘾相关行为的神经机制及其干预提供新的思路。

更多论文详细内容：

Neuron：“减肥药”为何能降低饮酒冲动？朱英杰/陈子君团队揭示GLP-1类药物限制酒精奖赏与饮酒行为的关键机制

JCI：减肥“神药”背后的机制——朱英杰团队揭示“减肥药”GLP-1R激动剂的全新中枢作用靶点

Nature子刊：深圳先进院朱英杰团队发现调控享乐性进食的神经环路

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往期讲座回顾：

Cell Press脑科学讲坛| 张力团队报道乳酸在运动改善情感障碍中的新机制

Cell Press脑科学一作讲坛| 梅峰教授团队最新Neuron：生长激素促进髓鞘形成改善低氧导致的脑白质损伤

Cell Press脑科学一作讲坛| Neuron：大脑皮层发育障碍中的关键机制

Cell Press脑科学一作讲坛| Cell一作解读帕金森病的新型PET示踪剂

Cell Press脑科学一作讲坛预告| 抑郁症的神经调控康复机制

Neuron一作报告：胡海岚教授团队介绍抑郁研究新成果

Cell Press脑科学讲坛| Cell第一作者解读喷嚏和咳嗽的感觉神经通路

Cell Press讲坛| 罗敏敏团队Neuron一作解读调控厌恶感的新神经环路机制

Cell Press脑科学讲坛| 段树民院士团队Neuron一作解读大脑调控攻击行为性别差异性

Cell Press脑科学一作讲坛| 武胜昔/罗层团队Neuron揭示靶向初级运动皮层改善慢性疼痛的感觉-运动互作新环路机制

Cell Press脑科学一作讲坛| 杜久林团队Cell一作解读脑膜淋巴系统的胶质调控

Cell Press脑科学一作讲坛| 舒友生团队Neuron揭示孤独症高风险基因SCN2A的致病机制研究

Cell Press脑科学一作讲坛预告| 清华苑克鑫团队Cell一作报告基于离子液体的生物组织玻璃态透明化技术

Cell Press脑科学一作讲坛预告| 空医大唐都医院屈延团队Neuron一作揭示全新小胶质细胞亚群在急性脑损伤后的关键作用

Cell Press脑科学一作讲坛预告| 西京医院Neuron一作报告脊髓疼痛“闸门”失控核心机制

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  1. CONNECT:[ UseTime:0.000653s ] mysql:host=127.0.0.1;port=3306;dbname=c460;charset=utf8mb4
  2. SHOW FULL COLUMNS FROM `fenlei` [ RunTime:0.001034s ]
  3. SELECT * FROM `fenlei` WHERE `fid` = 0 [ RunTime:0.016686s ]
  4. SELECT * FROM `fenlei` WHERE `fid` = 63 [ RunTime:0.000309s ]
  5. SHOW FULL COLUMNS FROM `set` [ RunTime:0.000585s ]
  6. SELECT * FROM `set` [ RunTime:0.000211s ]
  7. SHOW FULL COLUMNS FROM `article` [ RunTime:0.000583s ]
  8. SELECT * FROM `article` WHERE `id` = 580071 LIMIT 1 [ RunTime:0.000511s ]
  9. UPDATE `article` SET `lasttime` = 1782633118 WHERE `id` = 580071 [ RunTime:0.003385s ]
  10. SELECT * FROM `fenlei` WHERE `id` = 64 LIMIT 1 [ RunTime:0.000279s ]
  11. SELECT * FROM `article` WHERE `id` < 580071 ORDER BY `id` DESC LIMIT 1 [ RunTime:0.000566s ]
  12. SELECT * FROM `article` WHERE `id` > 580071 ORDER BY `id` ASC LIMIT 1 [ RunTime:0.006577s ]
  13. SELECT * FROM `article` WHERE `id` < 580071 ORDER BY `id` DESC LIMIT 10 [ RunTime:0.006760s ]
  14. SELECT * FROM `article` WHERE `id` < 580071 ORDER BY `id` DESC LIMIT 10,10 [ RunTime:0.028175s ]
  15. SELECT * FROM `article` WHERE `id` < 580071 ORDER BY `id` DESC LIMIT 20,10 [ RunTime:0.013471s ]
0.146603s